France winger Gabin Villiere has been ruled out of their November tests with an injury, a source told AFP on Monday.
Toulon's Villiere, 29, last played in July due to a finger issue and has recently undergone surgery for a groin problem.
Villiere started two of France's three July test losses to New Zealand with regular starters Damian Penaud and Louis Bielle-Biarrey rested.
Coach Fabien Galthie will also be without captain Antoine Dupont, tight-head prop Uini Atonio and centre Yoram Moefana because of injuries for three internationals later this year.
Les Bleus play South Africa on 8 November, Fiji a week later and then Australia on 22 November.