Pakistan paceman Shaheen Shah Afridi grabbed four wickets to limit England to 241 despite a fighting century by Ben Duckett in Lahore on Sunday.
Battling to stay in the tri-series after losing their first two games, England never fully recovered after slipping to 19 for three on a batting-friendly pitch.
Duckett resisted with a knock of 105 off 111 balls and Sam Curran scored 42 during a 93-run fifth-wicket stand, while Gus Atkinson contributed an unbeaten 36 at the bottom of the order.
Shaheen claimed 4-46 while Razaullah took 2-38 on his ODI debut as England were bowled out in 46.4 overs.
Duckett hit 10 fours and two sixes before falling to spinner Arafat Minhas, who finished with 2-26.
Opting to bowl first, Shaheen removed Tom Banton for four in the opening over - his 150th ODI wicket.
The lanky left-armer is the 13th bowler from Pakistan to take 150 or more wickets.
In his next over, Shaheen got the prized wicket of Joe Root for five, caught cutting a short delivery.
England plunged into further trouble when Harry Brook - who scored the fastest-ever ODI double century in his team's shock defeat to Sri Lanka - was run out for one.
Duckett's fifth ODI hundred and Curran's resolute batting briefly steadied England before Shaheen took two more wickets to end the innings.