Watford manager Claudio Ranieri was sacked on Monday after only 14 games in charge of the Premier League strugglers.
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Ranieri was hired in October to replace Xisco Munoz after the Spaniard's dismissal.
But the 70-year-old Italian was unable to improve Watford's fortunes, with the Hornets taking just seven points during his brief reign.
Just 112 days after his appointment, Ranieri paid the price for Watford's slump into the relegation zone following last week's 3-0 defeat against relegation rivals Norwich.
"Watford Football Club confirms the departure of Head Coach Claudio Ranieri," a club statement said.
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Watford are second bottom of the table, two points from safety, after losing seven of their last eight league games.
They are without a victory in nine games in all competitions, their longest winless run since 2013.
Watford's owners, the Pozzo family, felt they had to act now to give the team a chance as they battle to avoid relegation after last season's promotion from the Championship.
"The Hornets' Board recognises Claudio as a man of great integrity and honour, who will always be respected here at Vicarage Road for his efforts in leading the team with dignity," the statement said.
"However the Board feels that, with nearly half of the Premier League campaign remaining, a change in the Head Coach position now will give a new appointment sufficient time to work with a talented squad to achieve the immediate goal of retaining Premier League status.
"No further club comment will be made until this new appointment is confirmed in due course.”