Ethiopian Insurance and Mekelakeya, two of the strong challengers go head-to-head at the Adama Science and Technology University Stadium.
The Ethiopian Premier league week six fixture precedes the early relegation battle between struggling Shashemene City and Wolkite City.
Ethiopia Insurance are 10th on the log with 5 points. They have won only one game from their first five fixtures.
They have in addition been unable to score regularly with only four goals in their first five matches.
Mekelakeya on the other hand lie third with 10 points after winning three of their five matches so far.
They will be without Kenean Markneh and Bereket Desta for this match following injuries to both.
Both teams have met 14 times before with Ethiopian Insurance tops with seven wins and Mekelakeya on five wins and two draws between them.
Wolkite City survived relegation in the last game of the last season, and they have been dragged right into it very early along with opponents, Shashemene City.
They will both will be looking for a first win of the season.
Shashmene City are in 16th place, and bottom of the log with only one point earned from a draw and four losses out of five matches.
They are under new coach Zemariyam Woldegiorgis as Tsegaye Wondimu has departed from the team.
Wolkite City are led by Mulugeta Mihret who has yet to change their fortunes.
They are ranked one place above their opponents of the day with two points I'm 15th place.