Manchester City's hopes of a trophy this season now rest solely on the FA Cup ahead of Saturday's visit of second-tier Plymouth, while holders Manchester United also desperately need silverware to rescue a miserable campaign.
With Premier League leaders Liverpool, Arsenal, Chelsea and Tottenham already out, the path has been cleared for the Manchester giants, who have faced off in each of the past two finals.
The #EmiratesFACup fifth round schedule has been confirmed! ⤵️
— Emirates FA Cup (@EmiratesFACup) February 14, 2025
Brighton, Newcastle and Crystal Palace are among the other clubs who are dreaming of glory come Wembley on May 17.
AFP Sport looks at the pick of the ties from the fifth round this weekend:
Crystal Palace v Millwall (Saturday 12:15 GMT)
Twice FA Cup runners-up, Palace have never won a major trophy but are coming into form at the right time if they are to reach Wembley this year.
Alexander Isak’s glow-up has been crazy! The Newcastle baller has turned into one of the most lethal strikers - not just in England, but worldwide. His secret? Straight-up grind and pure determination 💪
— Emirates FA Cup (@EmiratesFACup) February 28, 2025
Born in Solna, Sweden, he started at AIK, breaking records as their… pic.twitter.com/6XCAEotHfc
Oliver Glasner's men have won seven of their last nine games in all competitions, most recently thrashing Aston Villa 4-1 in midweek.
Jean-Phillippe Mateta's streak of eight goals in nine games has helped the Eagles soar clear of any relegation trouble and up to 12th in the Premier League.
Matheus Cunha’s rise to stardom has been all about hard work from the start 🌟
— Emirates FA Cup (@EmiratesFACup) February 27, 2025
Born in Brazil, he made his European debut at Swiss side Sion, where he quickly impressed with 10 goals and 8 assists in just 32 games as a teenager. Next, Germany’s RB Leipzig came calling, where he… pic.twitter.com/JTv1O68ApU
Now they face a local derby against Championship side Millwall, who are keen to spoil the ambitions of their south London rivals.
Man City v Plymouth (Saturday 17:30)
Plymouth were the story of the fourth round as they stunned Liverpool 1-0 at Home Park.
Argyle's reward is a trip to the Etihad and a shot at another monumental shock.
Round two incoming! @afcbournemouth face off against @Wolves in the #EmiratesFACup this weekend, fresh off last week’s Premier League clash where Wolves took the win 🐺
— Emirates FA Cup (@EmiratesFACup) February 27, 2025
Who’s coming out on top this time? 👇 pic.twitter.com/LfWec9j9Ia
Plymouth boss Miron Muslic has become an internet sensation after clips of his inspirational team talks went viral and is looking forward to coming up against his coaching idol Pep Guardiola.
"It's the biggest honour in my life," said Muslic.
"I'm very much looking forward to shaking his hand and telling him that he's a giant of our sport and a huge, huge role model for every single coach in the world."
Newcastle v Brighton (Sunday 13:45)
Arguably the tie of the round sees sixth in the Premier League take on eighth.
Newcastle, two places above Brighton in the table, already have one final to look forward to next month, against Liverpool in the League Cup.
The Magpies have not won a major trophy for 56 years but can ill-afford to let the success or failure of their season hang on a clash with the Premier League champions-elect.
Ipswich Town are back in the #EmiratesFACup fifth round 👀
— Emirates FA Cup (@EmiratesFACup) February 26, 2025
Their match with @NFFC on Monday will be their first appearance at this stage since the 2006-07 season 🔥 pic.twitter.com/vdSY8Pnb2L
Brighton have won four in a row after a difficult spell in Fabian Hurzeler's first season in charge.
The Seagulls won at St James' Park earlier in the season and often save their best for the toughest opposition.
Much will depend on the fitness of Newcastle's 21-goal striker Alexander Isak, who missed Wednesday's 2-0 defeat at Liverpool due to a groin strain.
Man Utd v Fulham (Sunday 16:30)
United saved a shambolic campaign last season by beating City to lift the Cup but few can see Ruben Amorim's men repeating the feat.
The Red Devils did show heart in beating Ipswich 3-2 on Wednesday despite Patrick Dorgu's first-half red card for just a third league win in 11 matches.
Fulham sit five places and nine points above United in the Premier League, but have lost both meetings between the sides 1-0 this season.
The Cottagers not only have revenge for those matches in mind, but also for a controversial FA Cup quarterfinal at Old Trafford two years ago.
Fulham led 1-0 with 15 minutes to go until captain Aleksandar Mitrovic, Willian and manager Marco Silva were all sent off following a handball on his own line by Willian.
United went on to win 3-1 and Mitrovic received an eight-game ban for pushing referee Chris Kavanagh.