West Indies captain Roston Chase ripped through Bangladesh's top order to leave the hosts reeling at 79-6 on the third day of the first test in Mirpur on Friday.
Bangladesh held a 106-run lead at stumps, with concussion substitute Jaker Ali and Nayeem Hasan – both on 18 – at the crease when bad light stopped play early.
Earlier, offspinner Nayeem took four wickets to bowl West Indies out for 245, conceding a lead of 27 runs in response to Bangladesh's first-innings total of 272.
West Indies resumed the day on 134-4 and continued to frustrate Bangladesh through a fifth-wicket partnership between Tagenarine Chanderpaul, who top-scored with 56, and Justin Greaves.
The pair added 65 runs before Shoriful Islam broke the stand, with Chanderpaul edging to second slip where captain Najmul Hossain Shanto took a sharp catch.
Bangladesh had to wait for another breakthrough as Greaves kept up the defiance with skipper Chase, who made an unbeaten 43 after being dropped on 27, for company.
Offspinner Nayeem broke through by trapping Greaves lbw for 46 shortly before lunch, leaving West Indies at 213-6.
Chase came out attacking, while Joshua Bishop contributed 15 before being stumped off Mehidy Hasan Miraz.
Bishop had earlier been dropped on 11 by Mominul Haque at short leg, with the Bangladesh batter suffering concussion while attempting the catch and was replaced by Jaker.
Nayeem, who took 4-33, then cleaned up the tail, removing Shamar Joseph and Jomel Warrican in the 81st over before dismissing Jayden Seales in the next.
West Indies fast bowler Joseph struck in the second over to send back opener Tanzid Hasan for a duck.
Shadman Islam, who scored 105 in the first innings, and Shanto briefly steadied things before Chase took control and bowled the opener for 13.
Chase had Towhid Hridoy out for a duck two balls later and trapped skipper Najmul Hossain Shanto lbw for 10 in his next over to leave Bangladesh tottering at 33-4 before rain interrupted play for around 30 minutes.
West Indies continued their assault after the break as Warrican trapped Litton Das lbw for four before bowling Mehidy Hasan Miraz to reduce Bangladesh to 53-6.
BANGLADESH: Shadman Islam, Tanzid Hasan, Mominul Haque, Najmul Hossain Shanto (capt), Towhid Hridoy, Litton Das (wk), Mehidy Hasan Miraz, Nayeem Hasan, Taijul Islam, Hasan Mahmud, Shoriful Islam.
WEST INDIES: John Campbell, Brandon King, Tagenarine Chanderpaul, Kavem Hodge, Amir Jangoo (wk), Roston Chase (capt), Justin Greaves, Joshua Bishop, Shamar Joseph, Jomel Warrican, Jayden Seales.