Ethan Nwaneri missed the decisive spot-kick as Marseille crashed out of the French Cup quarterfinals on penalties against Toulouse on Wednesday after a 2-2 draw in which they twice led.
Mason Greenwood's second-minute penalty put Marseille ahead at the Velodrome, but Yann Gboho soon equalised for Toulouse.
Igor Paixao's excellent curling finish restored the lead for the hosts early in the second half before Charlie Cresswell powered in a header from a corner to bring Toulouse level again.
Marseille captain Leonardo Balerdi had his penalty saved in the shootout and Arsenal loanee Nwaneri blazed his effort over, dashing the club's hopes of lifting the cup for the first time since 1989.
Toulouse, who won the competition three years ago, go into the semifinals along with Nice and Strasbourg.
Nice edged past Lorient 6-5 on penalties following a goalless draw in Brittany, where the hosts played more than half the match with 10 men after Pablo Pagis was sent off just before the interval.
Strasbourg beat last season's runners-up Reims 2-1 on Tuesday. Lyon host Lens in the remaining quarterfinal on Thursday.