Ethiopia Nigd Bank also known as CBE - Commercial Bank of Ethiopia will go 6 points clear if they beat Sidama Coffee on Sunday.
That is of course if closest challengers, Mekelakeya fail to beat Ethiopia Coffee in the second game at Dire Dawa International Stadium.
Both are mouthwatering Ethiopia Premier League week 22 matches which will end another exciting week for teams at both ends of the table.
Ethiopia Coffee and Mekelakeya face each other with a seven points gap between them with Coffee in 6th place on 33 points and Mekelakeya in second place on 40 points.
Ethiopia Coffee's form in the games at Dire Dawa, shows two wins, one draw and three losses including their last game, 0-1 to Adama City.
The match was their only match in which they finished without scoring after 5 matches. The team has 30 goals this season more than their opponent Mekelakeya, who have scored 27.
Mekelakeya will once again be led by their head coach Gebrekirstos Birara after he completed his four-match ban.
The winning rate is the same for both sides but Mekelakeya's defeat by Ethiopian Insurance was unexpected from the past game.
The final game of 22 sees the flying Commercial Bank of Ethiopia up against Sidama Coffee.
The Bankers are back to winning ways after losing points in three matches, they won back-to-back.
They have also ramped up their goalscoring going from scoring one goal each in two games to scoring seven in the last two matches.
They are also the strongest attacking team in the league with 37 goals.
Sidama Coffee on the other hand dropped to 11th place with 27 points after wins by Hawassa and Wolaitta Dicha in the past two days moved both above them.
However, Sidama are on a good run of form and have been unbeaten in the last five matches, winning two games, and three draws.
They will be confident of completing a double over the League leaders having won the first- round tie by 2 - 1.