Jose Mourinho's Roma fell to their third Serie A defeat of the season 4-1 at Genoa on Thursday leaving the capital side just above the relegation zone.
Albert Gudmundsson fired the north-western port side ahead after five minutes before Bryan Cristante equalised after 22 minutes.
But Genoa came out firing after the break with Gudmundsson and Morten Thorsby combining superbly to set up Mateo Retegui to finish off with a half-volley.
Thorsby added a third after 74 minutes with Junior Messias sending in the fourth seven minutes later through a porous Roman defence.
🔥 SUPER GENOA 🔴🔵
— Genoa CFC (@GenoaCFC) September 28, 2023
✌️ Il Grifo batte la Roma al Ferraris!
⏹️ FT: #GenoaRoma 4️⃣-1️⃣ pic.twitter.com/C3oYp3RfLX
Watching from the stands, Roma legend Francesco Totti left the Luigi-Ferraris stadium after Genoa's fourth goal.
Aiming for a return to the Champions League next season, Mourinho's side find themselves fighting to remain in the top flight.
Roma are 16th with five points from six games, 10 points behind leaders Inter Milan, and only two clear of Udinese who currently occupy 18th place.
Genoa jumped to 11th place with seven points after their second win of the season.
Earlier, Monza and Bologna drew 0-0, with Frosinone grabbing a 1-1 draw with Fiorentina.