Olympiakos and Bayer Leverkusen have faced on three previous occasions in the UEFA Champions League – the Greek side have won two of those (L1), with the most recent coming last month: a 2-0 home win on MD7 of the league phase.

Bayer Leverkusen have only won one of their five away games against Greek sides in Europe (4-1 v Panathinaikos in October 1993), failing to win on each their four trips there since the turn of the millennium (D2 L2), and failing to score in three of those.