Ajax and Olympiakos have faced each other six times in European competition, with both sides winning two games apiece (D2). All four victories achieved in this fixture have been by the home side (two each).

This will be the first meeting between Ajax and Olympiakos this century, having last met in the 1998-99 edition of the UEFA Champions League – the Greek side won 1-0 at home in the first game that season, before Ajax won 2-0 in the reverse fixture in Amsterdam.