Borussia Dortmund and Internazionale have faced each other on six previous occasions in Europe, with the most frequent result being an Inter victory (3 – two wins for Dortmund and one draw).

The last meeting between Borussia Dortmund and Internazionale was a 3-2 victory for the German side in November 2019 – a game that Inter led 2-0 in at half time. This remains the only time that Dortmund have trailed by 2+ goals at half time of a European Cup/UEFA Champions League game and gone on to win, as well as the only time Inter have led by 2+ goals at the break and lost in those competitions.