AC Milan winger Christian Pulisic and Juventus forward Timothy Weah have both been ruled out of the United States squad for the upcoming CONCACAF Nations League qualifiers with Trinidad and Tobago.
USA coach Gregg Berhalter named his 24-man squad for the pair of games against the Caribbean team on Thursday and the two wide-men were the most noticable absences.
A US Soccer Federation spokesman confirmed that the duo were both missing due to injuries.
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Pulisic was substituted in stoppage time of AC Milan's 2-1 win over Paris Saint German in the Champions League on Tuesday after pulling up with a leg muscle injury.
Weah has been sidelined since suffering a hamstring injury for Juventus against Verona in Serie A last month.
Berhalter remains without another key starter with central midfielder Tyler Adams ruled out until February after a setback in his attempt to return from long-term injury in September.
The USA will face Trinidad and Tobago in Austin, Texas, on 16 November before taking on the same opponents in Port of Spain four days later.
SQUAD
Goalkeepers: Matt Turner, Nottingham Forest (ENG); Ethan Horvath, Nottingham Forest (ENG); Gaga Slonina, Eupen (BEL)
Defenders: Cameron Carter-Vickers, Celtic (SCO); Sergino Dest, PSV Eindhoven (NED); Tim Ream, Fulham (ENG); Antonee Robinson, Fulham (ENG); Kristoffer Lund, Palermo (ITA); Chris Richards, Crystal Palace (ENG); Miles Robinson, Atlanta United (USA); Joe Scally, Borussia Moenchengladbach (GER)
Midfielders: Weston McKennie, Juventus (ITA); Yunus Musah, AC Milan (ITA); Gio Reyna, Borussia Dortmund (GER); Paxten Aaronson, Eintracht Frankfurt (GER); Johnny Cardoso, Internacional (BRA); Luca de la Torre, Celta Vigo (SPA); Lennard Maloney, Heidenheim (GER); Malik Tillman, PSV Eindhoven (NED)
Forwards: Brenden Aaronson, Union Berlin (GER); Folarin Balogun, Monaco (FRA); Kevin Paredes, Wolfsburg (GER); Ricardo Pepi, PSV Eindhoven (NED); Alex Zendejas, Club America (MEX).