Manchester City will face Liverpool in a blockbuster FA Cup quarterfinal, while quadruple-chasing Arsenal travel to Southampton.
Monday's draw for the last eight also handed Chelsea a home tie against League One giant-killers Port Vale, who stunned Sunderland with a 1-0 win in the fifth round on Sunday.
West Ham or Brentford, who meet on Monday, will host Leeds in the other quarterfinal.
But it is City's latest showdown with rivals Liverpool that is the stand-out tie of the round.
Pep Guardiola's side have already beaten Liverpool twice this season, winning 3-0 in Manchester in November and earning a 2-1 victory at Anfield in February.
The #EmiratesFACup quarter-final draw 🏆
— Emirates FA Cup (@EmiratesFACup) March 9, 2026
It will be the first FA Cup meeting between the clubs since Liverpool won 3-2 in the semifinals in 2022.
Liverpool, 3-1 winners at Wolves in the last 16, have won the FA Cup eight times, most recently four years ago.
Seven-time winners City, who beat Newcastle 3-1 in the fifth round, last lifted the trophy in 2023.
Premier League leaders Arsenal advanced to the quarterfinals with a 2-1 win at third tier Mansfield.
Mikel Arteta's men will head to Championship playoff hopefuls Southampton, who enjoyed a surprise 1-0 win at Fulham in the fifth round.
QUARTERFINAL DRAW
Southampton v Arsenal
Chelsea v Port Vale
Manchester City v Liverpool
West Ham or Brentford v Leeds
Ties to be played around the weekend of April 4-5.