With Cape Town City continuing their surge up the Motsepe Foundation Championship table, the Citizens will face NWU in their next league clash, while Magesi could make it five wins on the bounce when they face Hungry Lions on Sunday.
City appears to have overcome their slow start to the campaign after an opening day 2-1 defeat against Real Native, followed by a 1-1 draw with Leicesterford City thereafter.
Now on a run of two consecutive wins, Fourth-placed City will take on NWU on Saturday, with the latter yet to taste victory in the league this season. Overall NWU recorded two draws and two losses from their first four matches, leaving them in 14th position on the log.
Magesi, who sit in pole position on the standings heading into matchday five, are scheduled to take on Magesi at home on Sunday.
The Motsepe Foundation Championship leaders recorded consecutive wins over Midlands Wanderers, The Bees, Leicesterford City, and Highbury to commence the campaign, while Hungry Lions recorded their first win last time out.
Lions will head into their next tie on the back of a 2-0 win over The Bees, following two draws and one defeat in their first three fixtures, placing them in 10th place on the table.
Elsewhere, The Bees will hope to overcome their four-match losing streak when they face Lerumo Lions on Saturday. With no points this season, The Bees will take on a side who likewise suffered defeat in their most recent assignment after a narrow 1-0 home loss against Real Native on 12 September.
As it stands, The Bees sit at the bottom of the table while Lerumo Lions find themselves in fifth place after four matches.
Second-positioned Real Native could make it three wins on the spin when they face Venda Football Academy on Friday, with the latter occupying 15th on the log after three straight losses.
Motsepe Foundation Championship fixtures:
Friday, 18 September
3pm: Real Native v Venda Football Academy
3pm: Highbury v Gomora United
Saturday, 19 September
3pm: Hope FC v Orbit College
3pm: The Bees v Lerumo Lions
3pm: NWU v Cape Town City
3pm: Upington City v University of Pretoria
3pm: Leicesterford City v Midlands Wanderers
Sunday, 20 September
3pm: Magesi v Hungry Lions