European football's biggest club competition returns with a packed schedule featuring heavyweight clashes, intriguing storylines and key league-phase points up for grabs.
All matches will be broadcast live on SuperSport and DStv Streaming.
Feyenoord v Como (6:45pm)
Feyenoord will fancy their chances of continuing their impressive home form in Europe when they welcome Champions League newcomers Como. The Dutch side have won four of their last five Champions League matches at home and are targeting a third consecutive league-phase victory in Rotterdam.
The hosts have also shown resilience when in front, winning their last nine Champions League games after leading at halftime. While Feyenoord's record against Italian opposition is modest, they have scored consistently on the continental stage, failing to find the net in only two of their last 16 league-phase matches.
Como arrive with confidence from midfielder Martin Baturina, who has scored in successive Champions League appearances and will be a key creative outlet as the Italian side look to cause an upset.
Key stat: Feyenoord have won four of their last five Champions League home matches.
LASK v Liverpool (6:45pm)
Liverpool head to Austria as overwhelming favourites against a LASK side still searching for a breakthrough result against English opposition.
The Austrian club are winless in six matches against English teams and have not won any of their last nine European group or league-phase encounters. Liverpool, meanwhile, boast an excellent record against Austrian opposition, winning eight of their ten meetings and remaining unbeaten away from home.
Dominik Szoboszlai returns to familiar territory having enjoyed considerable success against LASK during his Salzburg days, while Cody Gakpo will have happy memories after scoring twice in Liverpool's 4-0 victory over LASK in the Europa League two seasons ago.
Key stat: Liverpool have won 19 of their last 22 Champions League group-stage and league-phase matches.
Roma v Real Madrid
One of the headline encounters sees Roma host record champions Real Madrid in the Eternal City.
Madrid have dominated this fixture historically, winning eight of the 12 meetings between the clubs and triumphing in each of the last four without conceding a goal. The Spanish giants have also won five of their previous six visits to Rome.
Roma's home form offers encouragement, however, with the Italians winning eight of their last nine Champions League matches on home soil.
All eyes will be on Kylian Mbappé, who could become the youngest player in Champions League history to reach 100 appearances. Madrid's remarkable recent record against Italian clubs is another warning sign for the hosts, with Los Blancos winning 20 of their last 22 matches against Serie A opposition.
Key stat: Real Madrid have won 20 of their last 22 matches against Italian clubs.
Aston Villa v Fenerbahçe
Villa Park has become one of Europe's toughest away venues and Unai Emery's side will be confident of extending their impressive home streak against Turkish giants Fenerbahçe.
Villa are unbeaten in 13 home European matches, winning the last ten, while they have won all three previous meetings against Fenerbahçe without conceding.
The visitors do possess dangerous attacking threats, including Romelu Lukaku, who has scored eight goals in his last seven matches against Villa. Marco Asensio also returns to a ground where he enjoyed a productive loan spell.
Fenerbahçe's recent Champions League struggles remain a concern, with the Turkish side winless in their last eight matches in the competition.
Key stat: Aston Villa have won their last 10 home European matches.
Shakhtar Donetsk v AEK Athens
Two teams carrying solid European form face off in what could be one of the most evenly matched ties of the evening.
Shakhtar are unbeaten against Greek opposition and have lost only four of their last 21 UEFA competition matches. The Ukrainians have often started strongly, leading at halftime in four of their last six Champions League matches.
AEK Athens, however, arrive with confidence after losing just three of their last 20 UEFA fixtures. Former Shakhtar player Oleksandr Zubkov will add an intriguing subplot as he returns to face his old club.
Key stat: AEK Athens have lost only three of their last 20 UEFA competition matches.
Bodø/Glimt v Borussia Dortmund
Expect goals when Norwegian champions Bodø/Glimt host Borussia Dortmund.
The sides shared an entertaining 2-2 draw in last season's league phase and another open contest could be on the cards. Bodø/Glimt have won their last five UEFA home matches, scoring exactly three goals in each game.
Dortmund striker Serhou Guirassy continues his rapid rise in European football and could climb further up the list of players with the most goals in their first 30 Champions League appearances.
The German side's recent Champions League games have been highly entertaining, producing an incredible average of more than four goals per match across their last 17 league-phase outings.
Key stat: Dortmund's last 17 league-phase matches have produced 75 goals.
Manchester City v Paris Saint-Germain
The glamour tie of the night pits Manchester City against Paris Saint-Germain in a clash loaded with world-class talent.
City have historically held the edge in this rivalry, although PSG claimed a memorable 4-2 victory in their most recent meeting. Pep Guardiola's team remain formidable at the Etihad, losing just one of their last 25 Champions League home league-phase matches.
Erling Haaland enters the contest on the verge of another remarkable milestone, with 59 goals in 59 Champions League appearances. PSG arrive in strong form against English opposition and have not lost any of their last 11 UEFA matches against Premier League clubs.
Ousmane Dembélé's red-hot scoring streak adds further intrigue to a contest that could have significant implications near the top of the league-phase standings.
Key stat: Erling Haaland has scored 59 goals in just 59 Champions League appearances.
Real Betis v Porto
Real Betis and Porto meet in Seville in a contest that promises goals.
Only one of Betis' last 48 UEFA matches has finished goalless, while Porto have not played out a 0-0 draw in any of their last 31 European fixtures.
Betis have been particularly potent at home, scoring at least two goals in each of their last nine European matches in Seville. Porto's recent struggles against Spanish opposition suggest the hosts may hold a slight advantage.
Key stat: Betis have scored two or more goals in their last nine home European matches.
Slovan Bratislava v Stuttgart
Stuttgart return to face familiar opposition after defeating Slovan Bratislava 3-1 in last season's league phase.
The Slovak champions have found life difficult in the Champions League, losing all nine matches they've played in the competition. However, they have managed to score in each of their last six Champions League outings.
Stuttgart boast an unbeaten record against Slovakian opposition and will view this fixture as an opportunity to collect valuable away points.
Key stat: Stuttgart are unbeaten in seven matches against Slovakian teams.