Liverpool piled on the misery for Manchester City as the Premier League leaders beat the troubled champions 2-0 at Anfield, while Manchester United boss Ruben Amorim earned his first league win with a 4-0 rout of Everton on Sunday.
Arne Slot's side moved nine points clear of second-placed Arsenal after Cody Gakpo's first-half opener and Mohamed Salah's late penalty dealt another blow to reeling City, who are languishing 11 points behind Liverpool in fifth place.
City have lost four successive top-flight games for the first time since 2008, making them the first Premier League champions to endure such a dismal run the year after claiming the title.
In the 32 Premier League seasons, only three times have teams come from 11 or more points behind at any point to win the title.
City have clawed back significant deficits to win the Premier League in the Guardiola era, but they have never managed to lift the title after being behind by more than 10 points.
City's seven-game winless run ranks as boss Pep Guardiola's longest barren streak in his glittering managerial career.
Just weeks after he signed a new two-year contract, Liverpool fans taunted Guardiola with chants of "you're getting sacked in the morning", prompting a defiant response from the Spaniard, who held up six fingers to illustrate the number of titles he has won with City.
Liverpool have won 18 of their 20 games in all competitions since Slot replaced Jurgen Klopp in the close-season.
The Reds have won 11 of their 13 Premier League matches and are firm favourites to win the title for the first time since 2020.
Guardiola sprang a surprise by starting Stefan Ortega in goal instead of the dropped Ederson, but the German had to pick the ball out of his net after just 12 minutes.
City's defence was in disarray as Salah curled a shot towards the far post and Gakpo pounced to poke home from virtually on the line.
The Slot machine strikes early at Anfield 🤩⭐
— SuperSport Football ⚽️ (@SSFootball) December 1, 2024
We have a feeling we there are more goals on the menu 👀
📺 Stream #LIVMCI on DStv: https://t.co/B0jLrQW5cc pic.twitter.com/tlyLNzILHp
Salah's 78th-minute penalty, awarded for Ortega's foul on Luis Diaz, was a dagger in the heart of City's title hopes.
Amorim stole the spotlight in Sunday's early games by extending his unbeaten start with United to three matches.
United were held to a 1-1 draw at Ipswich in his first Premier League game last Sunday, before the Portuguese boss earned his maiden win with United in a 3-2 success against Bodo/Glimt at Old Trafford in the Europa League on Thursday.
MAN UTD POWER SURGE
The 39-year-old, who arrived from Sporting Lisbon to replace the sacked Erik ten Hag in November, has warned United would "suffer for a long period" before they can expect to challenge for the title.
This was the most encouraging result of Amorim's brief time at ninth-placed United as they recovered from a slow start to dispatch lowly Everton.
Marcus Rashford's 34th-minute drive from the edge of the area took a deflection off Jarrad Branthwaite before flashing into the net.
United struck again seven minutes later as Branthwaite lost possession to Amad Diallo and Bruno Fernandes teed up Joshua Zirkzee to convert with ease.
Rashford underlined United's superiority just 20 seconds after the interval as he applied a cool finish to Diallo's incisive pass for his seventh goal this season.
Zirkee struck again in the 64th minute with a composed strike from the influential Diallo's assist after shambolic Everton defending.
✅ 2 for Marcus Rashford
— SuperSport Football ⚽️ (@SSFootball) December 1, 2024
✅ 2 for Joshua Zirkzee
✨ 𝐓𝐡𝐞 𝐑𝐮𝐛𝐞𝐧 𝐀𝐦𝐨𝐫𝐢𝐦 𝐄𝐟𝐟𝐞𝐜𝐭 ✨
📺 Stream #MUNEVE on DStv: https://t.co/B0jLrQW5cc pic.twitter.com/U6nMupzy86
"The result was good but we were pragmatic. It was not pretty," Amorim said. "It is a rollercoaster. We have some moments when we are good but then we have moments when we have to suffer."
At Stamford Bridge, Chelsea extended their unbeaten run in all competitions to six games with a 3-0 win against Aston Villa, whose dismal winless streak reached eight matches.
Enzo Maresca's men look capable of securing Champions League qualification after a third successive win in the space of eight days moved them level on points with second-placed Arsenal.
Nicolas Jackson and Enzo Fernandez scored in the first half before Cole Palmer struck in the closing stages.
Seventh-placed Tottenham's top four hopes were dented by a 1-1 draw against 10-man Fulham.
Brennan Johnson slotted Tottenham into the lead from Timo Werner's 54th-minute pass, but Tom Cairney curled Fulham's equaliser into the far corner after 67 minutes.
Cairney was sent off with seven minutes left after his foul on Dejan Kulusevski was upgraded from referee Darren Bond's initial yellow card to a red after VAR intervened.