Manchester United manager Ruben Amorim expects Amad Diallo to miss the rest of the season with ankle ligament damage.
Diallo suffered the injury in training and Amorim confirmed before Sunday's Premier League game at Tottenham that the Ivory Coast winger is likely to be sidelined until next term.
Asked if Diallo would be out for the rest of the season, Amorim told Sky Sports: "I think so."
The 22-year-old has been one of the few bright points in a campaign to forget at Old Trafford, scoring six goals in his last 14 appearances in all competitions.
Diallo's long-term absence is a major blow to Amorim, who revealed ahead of the trip to north London that Kobbie Mainoo, Manuel Ugarte and Toby Collyer had picked up injuries in addition to Diallo's setback.
Christian Eriksen and Leny Yoro are also suffering from illness, while Lisandro Martinez recently sustained a season-ending anterior cruciate ligament injury.
"Amad was alone, Ugarte was a kick," Amorim added. "Toby and Kobbie they felt something during training.
"It is what it is but we have the kids, they have the opportunity to be on the bench and they are ready to play.
"It's a really hard season and we have to deal with that and we are doing that."
Asked if he felt like the world was against him, Amorim said: "I don't see it like that, sometimes things happen and there are seasons that everything happens at the same time.
"I know that Amad, if you follow all the big situations, the creation of danger in the opposite box, Amad was always there.
"Maybe we'll find new ways to create situations. Maybe we will find good things in this difficult moment."