All three Premier League meetings between Southampton and Brentford have been won by the home side, with each victory being by a margin of three goals. Saints won this exact fixture 4-1 last season.
Brentford have won their last two league games against Southampton, including a 3-0 victory in the reverse fixture this season. They last did the league double over Saints in 1958-59, while they've never won three in a row against them before in league competition.
Brentford are winless in all seven of their midweek (Tuesday, Wednesday, Thursday) Premier League games. They lost all five such matches last season, while drawing both games so far this term.
After beating Leicester 1-0, Southampton could win back-to-back home games in the Premier League for the first time since February 2022. However, Saints have fewer home points (9) and home wins (2) than any other side in the top-flight this term.
Brentford lost for the first time in 13 Premier League matches against Everton last time out – the Bees haven't lost consecutive games in the competition since February 2022.
Southampton are looking to keep three consecutive Premier League clean sheets for the first time since a run from December 2020 to January 2021. Their two clean sheets in their last two games are as many as they had kept in their first 24 league matches of the season beforehand.
Southampton have picked up seven points in four Premier League games under Rubén Sellés (W2 D1 L1), as many as they had in their previous 12 league matches before the Spaniard’s first in charge (W2 D1 L9).
Carlos Alcaraz could become only the second player to score in each of his first three home Premier League appearances for Southampton, after David Hirst, who did so when Saints played at the Dell in November 1997.
Bryan Mbeumo has been directly involved in three goals in his three Premier League games against Southampton (1 goal, 2 assists), scoring and assisting in Brentford's 3-0 win earlier this season.
No player has scored more than two Premier League goals at St. Mary’s Stadium for Southampton this season (Carlos Alcaraz, Joe Aribo, Romain Perraud all 2 each), the joint-lowest tally of goals any team’s top scorer at home in the competition has netted in 2022-23, along with Everton (Demarai Gray, Dwight McNeil both 2)