Real Madrid coach Carlo Ancelotti left goalkeeper Thibaut Courtois and defender Antonio Rudiger out of his squad to face Rayo Vallecano at home on Sunday.
Spanish media reported Rudiger was ill and Courtois has discomfort in his knee, but both are expected to return for the Champions League last-16 second leg clash against Atletico Madrid on Wednesday.
Champions Madrid are third, three points behind LaLiga leaders Barcelona and two behind Atletico, who face Getafe earlier on Sunday.
Barcelona's match against Osasuna on Saturday was postponed after the death of one of the Catalan club's doctors.