Barcelona will face Atletico Madrid in the Copa del Rey semifinals, while Real Madrid were pitted against Real Sociedad in Wednesday's draw.
It is the first time since 2014 that Spain's big three teams have reached the final four, with Real Sociedad also there on that occasion.
Record 31-time winners Barcelona, who last lifted the trophy in 2021, will host Diego Simeone's side in the first leg before visiting the Metropolitano stadium.
Atletico, second in LaLiga a point ahead of the Catalan giants, last lifted the trophy in 2013 and have won it on 10 occasions.
Spanish and European champions Real Madrid, 20-time cup winners, visit San Sebastian in the first leg before hosting Real Sociedad in the return.
Basque side Real Sociedad have only won the trophy twice, most recently claiming the 2020 edition.
The semifinal first legs will be played on February 25 and 26, with the return legs set for 1 and 2 April.