Lyon started their Women's Champions League campaign with a 3-0 win against Galatasaray on Tuesday, while two-time winners Wolfsburg suffered an opening-day defeat in Rome.
A trio of headers from Kadidiatou Diani, who scored twice, and Vanessa Gilles gave last year's beaten finalists Lyon a comfortable home victory over Turkish club Galatasaray.
France attacker Diani opened the scoring when she stole in to nod home a Tabitha Chawinga cross with 34 minutes on the clock.
Chawinga then got her second assist of the match – and Lyon scored their second goal – right on the stroke of halftime as Gilles turned in her chipped cross from close range.
Gilles went close with another header early in the second period, but her towering effort from a corner rattled against the crossbar.
Diani did make it three in the 77th minute when her guided header crept inside the far post after Amel Majri had burst down the left flank and drilled in a cross.
In the Italian capital, a 14th-minute penalty converted by new captain Manuela Giugliano was the difference between Roma and Wolfsburg.
The visitors struck the woodwork twice after the break but were left frustrated as Roma held on to take all three points and go second in Group A – behind Lyon on goal difference.
Group B starts later on Tuesday, with Chelsea hosting Real Madrid in the day's most hotly anticipated tie and Dutch side Twente making the trip to Celtic.
On Wednesday, Arsenal visit Bayern Munich and Champions League holders Barcelona start their title defence at Manchester City.