Former time-trial world champion Filippo Ganna pulled out of the Tour de France on Saturday's opening stage after struggling to shake off injuries from an early fall.
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The Italian Ineos rider would have been a contender on the lengthy stage 5 individual time-trial, having won the world title in 2020 and 2021.
It is also a blow to the British team's overall campaign to get veteran Geraint Thomas into the top 10 on his 14th and final Tour de France.