Brighton manager Roberto De Zerbi expects to be without wingers Kaoru Mitoma and Simon Adingra for between four to six weeks in the latest blows to his injury-hit squad.
Mitoma suffered an ankle problem during last week's 1-1 draw with Crystal Palace, with Adingra damaging his hamstring at Selhurst Park.
The pair are among up to 10 Seagulls players set to miss Thursday's match at home to Premier League high-flyers Tottenham.
"Tomorrow we have more or less 10 injured players, maybe eight but (the other) two players can't start the game," Brighton boss De Zerbi told a pre-match press conference on Wednesday.
"Mitoma is one of them. We lost Kaoru for around six weeks – four, five, six weeks. Adingra, I think he needs four, five weeks (recovery). Tomorrow, no Mitoma, no Adingra."
Japan international Mitoma is now a doubt for the Asian Cup, which begins on 12 January, while Ivory Coast forward Adingra's involvement in the Africa Cup of Nations, which starts the following day, uncertain.
South coast side Brighton, currently an impressive ninth in the table, will also be without Ansu Fati, Tariq Lamptey, Adam Webster, Solly March, Julio Enciso and Joel Veltman for the visit of Spurs, while midfielder Adam Lallana may only be fit for an appearance off the bench.