Crystal Palace will face Bosnian side Zrinjski for a spot in the UEFA Conference League last 16 after the sides were drawn together on Friday.
Palace missed out on a top-eight finish in the league phase, which would have guaranteed them direct progression to the round of 16, but were on the seeded half of the draw for the knock-out round playoffs.
As a result, the Eagles will play the second leg at their Selhurst Park home.
Their opponents finished the league phase in 23rd place with a record of two victories, one draw and three defeats.
Should Oliver Glasner's FA Cup winners progress, they will face either Bundesliga outfit Mainz or Cyprus' AEK Larnaca in the next round in March.
Two-time Conference League runners-up Fiorentina will face Jagiellonia of Poland, while Eredivisie side AZ Alkmaar drew Noah of Armenia.
Lech Poznan will take on Finland's KuPS Kuopio and Swiss side Lausanne meet Czechs Sigma Olomouc in some of the other choice play-off fixtures.
FRIDAY'S KNOCK-OUT ROUND PLAY-OFF DRAW IN FULL:
Zrinjski (BIH) v Crystal Palace (ENG)
KuPS Kuopio (FIN) v Lech Poznan (POL)
Shkendija (MKD) v Samsunspor (TUR)
Sigma Olomouc (CZE) v Lausanne (SUI)
Noah (ARM) v AZ Alkmaar (NED)
Jagiellonia (POL) v Fiorentina (ITA)
Drita (KOS) v Celje (SVN)
Omonoia (CYP) v Rijeka (CRO)
1st legs: Thursday, February 19
2nd legs: Thursday, February 26