South Africa prop Ox Nche will miss this year's Rugby Championship with a pectoral muscle issue, SA Rugby announced on Wednesday.
Nche, 27, sustained the injury on Tuesday and will be sidelined for Saturday's campaign-opening test with Australia, next weekend's trip to New Zealand and 29 July's game with Argentina.
The Sharks loose head had been named to start this weekend's game against the Wallabies. He has been replaced by Steven Kitshoff, who had been due to fly with an early travel party to New Zealand this week before the All Blacks game.
SA Rugby said Nche would be out for "several weeks" with the Rugby World Cup holders also playing three pre-tournament tests in August.
"We are particularly sad for Ox because he's been working very hard in the last few months and making a great contribution on and off the field," head coach Jacques Nienaber said in an SA Rugby statement.
"We wish him a speedy recovery.
"We've always emphasised the importance of being adaptable as a team and that will be particularly important this season with the Castle Lager Rugby Championship, World Cup warm-up games and the global showpiece itself coming up," he added.
South Africa start their defence of the World Cup on September 10 by playing Scotland and also face contenders Ireland as well as Romania and Tonga in the group stage.
SPRINGBOK TEAM TO FACE AUSTRALIA IN PRETORIA:
15 – Willie le Roux (Toyota Verblitz) – 83 caps, 65 pts (13t)
14 – Canan Moodie (Vodacom Bulls) – 4 caps, 5 pts (1t)
13 – Lukhanyo Am (Cell C Sharks) – 31 caps, 30 pts (6t)
12 – Andre Esterhuizen (Harlequins) – 11 caps, 0 pts
11 – Kurt-Lee Arendse (Vodacom Bulls) – 7 caps, 35 pts (7t)
10 – Manie Libbok (DHL Stormers) – 3 caps, 10 pts (5c)
9 – Cobus Reinach (Montpellier) – 24 caps, 45 pts (9t)
8 – Duane Vermeulen (captain, Ulster) – 65 caps, 15 pts (3t)
7 – Pieter-Steph du Toit (Toyota Verblitz) – 66 caps, 25 pts (5t)
6 – Marco van Staden (Vodacom Bulls) – 10 caps, 0 pts
5 – Marvin Orie (DHL Stormers) – 11 caps, 0 pts
4 – Jean Kleyn (Munster) – uncapped for SA (Ireland 5 caps)
3 – Frans Malherbe (DHL Stormers) – 58 caps, 5 pts (1t)
2 – Bongi Mbonambi (Cell C Sharks) – 56 caps, 60 pts (12t)
1 – Steven Kitshoff (DHL Stormers) – 71 caps, 5pts (1t)
REPLACEMENTS:
16 – Joseph Dweba (DHL Stormers) – 4 caps, 0 pts
17 – Thomas du Toit (Cell C Sharks) – 15 caps, 0 pts
18 – Vincent Koch (Stade Francais) – 41 caps, 0 pts
19 – RG Snyman (Munster) – 23 caps, 5 pts (1t)
20 – Evan Roos (DHL Stormers) – 3 caps, 0 pts
21 – Deon Fourie (DHL Stormers) – 5 caps, 0 pts
22 – Grant Williams (Cell C Sharks) – 1 cap, 0 pts
23 – Damian Willemse (DHL Stormers) – 27 caps, 36 pts (2t, 4c, 4p, 2d)