Brandon Paenga-Amosa will start at hooker for Australia against Scotland at Murrayfield on Sunday after Matt Faessler succumbed to a calf injury.
Faessler was selected in the team named by coach Joe Schmidt on Friday having been a standout performer in the 52-20 victory over Wales last weekend when he bagged a hat-trick of tries.
Billy Pollard will take the place of Paenga-Amosa, who earns a 19th cap, on the bench in what could be his fifth international appearance.
Paenga-Amosa's last international start was in 2021 against New Zealand.
Australia still have one more test to play in 2024 when they head to Dublin to meet Ireland on November 30.
Updated Australia team:
15-Tom Wright, 14-Andrew Kellaway, 13-Joseph Suaalii, 12-Len Ikitau, 11-Harry Potter, 10-Noah Lolesio, 9-Jake Gordon, 8-Harry Wilson, 7-Carlo Tizzano, 6-Rob Valetini, 5-Will Skelton, 4-Jeremy Williams, 3-Allan Alaalatoa, 2-Brandon Paenga-Amosa, 1-Angus Bell
Replacements: 16-Billy Pollard, 17-Isaac Kailea, 18-Zane Nonggorr, 19-Lukhan Salakaia-Loto, 20-Langi Gleeson, 21-Tate McDermott, 22-Ben Donaldson, 23-Max Jorgensen.