England flanker Tom Curry will miss the remaining Six Nations matches due to a hamstring injury after Sale Sharks director Alex Sanderson said the player will be out of action for "four to six weeks".
The 24-year-old withdrew from the England squad for Saturday's Six Nations game against Wales and was replaced by his brother Ben.
"Tom has a hamstring injury on the opposite leg to the one he did six weeks ago. It's a soft muscle that extends into the tendon and it's four to six weeks," Sanderson said.
"Tom played 80 minutes (for Sale Sharks) on Saturday and (was injured) on Monday — it is something to do with the physical demands of an international camp and he is frustrated."
England, who lost their opener against Scotland and beat Italy in the second game, face Wales at the Principality Stadium in Cardiff on Saturday. They then host France on March 11 and play away to Ireland on March 18.