Toulouse confirmed their place in the Top 14 semifinals and secured a first-place finish in the regular season with a 39-31 win over Lyon on Saturday, while Montpellier made sure of a playoff spot.
Three-time defending champions Toulouse will now wait to find out their opponents for the semifinals, to be played on June 19 in Marseille.
Ugo Mola's men were not at their best in their penultimate game of the regular season, but scored six tries against a Lyon side that had nothing left to play for and touched down four times themselves.
Winger Matthis Lebel gave Toulouse an ideal start, scoring his 14th try of the season after just three minutes, but Lyon responded, capitalising on Toulouse's lapses through Bartholome Sanson and then Esteban Gonzalez to lead 14-5.
Toulouse closed the gap thanks to prop Joel Merkler and then took the lead through Peato Mauvaka.
Capitalising on Lyon's indiscipline and yellow cards for Beka Shvangiradze and Leo Berdeu in the second half, Toulouse pulled away thanks to tries from Pierre-Louis Barassi, David Ainu'u, and Julien Marchand.
But Lyon kept up the pressure, with Josiah Maraku scoring a try on the counterattack after 50 minutes.
Jiuta Wainiqolo scored on the final whistle with his 18th try of the season.
Another positive for Toulouse was the return of Italian international Ange Capuozzo, who had been absent for over three months.
Montpellier moved into second place above Stade Francais and ensured at least a top-six finish with a 26-18 home victory over Pau.
La Rochelle thumped relegated Montauban 71-15 to boost their playoff hopes.