France centre Yoram Moefana, who missed the Six Nations win over Wales in Cardiff, has been ruled out of Les Bleus' next game against Italy, the French rugby federation (FFR) announced on Monday.
The FFR did not give a reason for Moefana's absence but the Bordeaux-Begles player missed the game in Wales after picking up a knee injury and coming off in the 50th minute in the tournament opener against Ireland.
Pau's Fabien Brau-Boirie, 20, took his place in the starting line-up, marking his first cap with a debut try in a 54-12 victory that leaves the French as the only side still able to win a Grand Slam.
Moefana will be replaced in the squad by Racing 92 flyhalf Ugo Seunes, who was playing second-division rugby with Aurillac last season.
Prop Tevita Tatafu, who was part of France's 42-man squad, has also been ruled out after picking up an injury in Bayonne's win over Racing 92 on Saturday.
He is replaced by Leinster's Rabah Slimani, who won the most recent of his 59 caps in New Zealand last year.