Paolo Garbisi will miss Italy's Six Nations clash with England this weekend as the Montpellier flyhalf continues his recovery from a knee injury suffered at the start of the year.
Garbisi, 22, had been named in the 30-man squad for Italy's first two matches in the tournament against France and England.
But he was again left out of Kieran Crowley's team for Sunday's trip to Twickenham, as he was for the clash with Les Bleus, and returns to his French Top 14 club.
"He has progressed very well. He has gone back to Montpellier with the hope of playing for them next weekend," Crowley told reporters on Friday.
"If he plays for them he will be joining us for the Ireland week and hopefully be available for selection for that game."
Crowley has made two changes to the team which suffered a narrow home defeat to France last weekend that highlighted the progress the Azzurri have made under him.
They came back from 19-6 down to briefly lead the Six Nations titleholders and World Cup favourites France before eventually losing 29-24 at the Stadio Olimpico in Rome.
"We took a big step forward against France, now we need another one against England," added Crowley.
Edoardo Padovani replaces Pierre Bruno at right wing while Saracens prop Marco Riccioni starts in the front row instead of Simone Ferrari, playing for the Azzurri for the first time since November 2021 against Argentina.
Gloucester flanker Jake Polledri is set for his first cap since November 2020 after being named on the bench.
"The most important thing is that they (Riccioni and Polledri) come in and they understand how we want to play. Their roles and working with other players in those roles," said Crowley.
England fell to a 29-23 Calcutta Cup defeat by Scotland last weekend.
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— Italrugby (@Federugby) February 10, 2023
Il Capo Allenatore Kieran #Crowley annuncia la formazione per il 2° match del @SixNationsRugby ?? https://t.co/nkVvMzqpa9
?????????????????? #ENGvITA
?? Twickenham Stadium - Londra
?? Domenica 12/02, kick off h 16 (ITA)
?? @SkySport ?? @NOWTV ?? @tv8 #rugbypassioneitaliana pic.twitter.com/Uqw2lpXhbr
ITALY: (15-1) Ange Capuozzo; Edoardo Padovani, Juan Ignacio Brex, Luca Morisi, Tommaso Menoncello; Tommaso Allan, Stephen Varney; Lorenzo Cannone, Michele Lamaro (capt), Sebastian Negri; Federico Ruzza, Niccolo Cannone; Marco Riccioni, Giacomo Nicotera, Danilo Fischetti
Replacements: Luca Bigi, Federico Zani, Simone Ferrari, Edoardo Iachizzi, Jake Polledri, Manuel Zuliani, Alessandro Fusco, Pierre Bruno