Hugo Keenan is the notable absentee from Andy Farrell's team as Ireland seek to make it three wins from three Six Nations matches against Wales at Lansdowne Road on Saturday.
Ciaran Frawley comes in at fullback for Keenan, who has failed to recover from a knee injury he suffered in the 36-0 victory over Italy a fortnight ago.
He will be sorely missed as the 27-year-old has been one of the outstanding players since Farrell took over after the 2019 Rugby World Cup.
Keenan had carried his sparkling World Cup form into the Six Nations but Frawley has deputised for him at fullback at Leinster, on eight occasions in the past two seasons.
Frawley, who will win his third cap but first as a starter, is also useful as he can fill in for Jack Crowley at fly-half, should anything go awry with the 24-year-old Munster playmaker.
Our team to face Wales in Dublin! 🟢#TeamOfUs
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Farrell, seeking unprecedented back to back Six Nations Grand Slams, has however been able to name 14 of the 15 that started the sublime 38-17 hammering of France in Marseille earlier this month.
Peter O'Mahony returns to captain the side, after missing the 36-0 victory over Italy with a calf injury.
It will be the 34-year-old backrow forward's 50th Six Nations appearance since his first match in the tournament back in 2012.
He returns at openside flanker which results in Caelan Doris, who also deputised for him as skipper against Italy, moving back to his favoured No 8 spot.
FORMIDABLE HOME RECORD
Doris had been a concern earlier in the week when he did not train on Tuesday due to a knock he suffered against Italy.
Others who return after sitting out the Italy whitewash are prop Tadgh Furlong and lock Tadgh Beirne, as well as Bundee Aki.
Aki teams up alongside Robbie Henshaw in the centres, with Gary Ringrose still sidelined due to a shoulder problem.
Jamison Gibson-Park resumes his budding halfback partnership with Crowley with the latter's Munster teammate Conor Murray providing back-up as scrum-half from the bench.
Farrell has reverted to the 6-2 forwards backs split on the replacements bench he deployed against the French, with prop Oli Jager poised for his first cap.
Ireland will be warm favourites not only due to their form thus far but also because they have had the better of the Welsh in recent contests, winning six of the last seven meetings.
The Irish have established a formidable record at home, winning 17 successive tests, while Wales have found Lansdowne Road a forbidding venue at which to play.
Although they won a 2015 Rugby World Cup warm-up match there, the Welsh have not come out on top in a Six Nations test in Dublin since a 23-21 victory in 2012.
TEAM (15-1):Ciaran Frawley; Calvin Nash, Robbie Henshaw, Bundee Aki, James Lowe; Jack Crowley, Jamison Gibson-Park; Caelan Doris, Josh van der Flier, Peter O'Mahony (capt); Tadhg Beirne, Joe McCarthy; Tadhg Furlong, Dan Sheehan, Andrew Porter
REPLACEMENTS: Ronan Kelleher, Cian Healy, Oli Jager, James Ryan, Ryan Baird, Jack Conan, Conor Murray, Stuart McCloskey
COACH: Andy Farrell (ENG)