Uini Atonio and Romain Taofifenua were named by France head coach Fabien Galthie on Thursday in the holders' starting lineup to face Wales in the Six Nations this weekend.
Tight-head prop Atonio comes in for Dorian Aldegheri, who has a groin issue, and lock Taofifenua replaces Paul Willemse, who sustained a hamstring injury in last Saturday's record 53-10 win over England.
New-Zealand-born Atonio, 32, will win his 50th cap at the Stade de France on Saturday as Les Bleus eye retaining their trophy with a bonus-point win if Ireland fail to claim a point against England in Dublin later in the day.
France
15 Thomas Ramos, 14 Damian Penaud, 13 Gael Fickou, 12 Jonathan Danty, 11 Ethan Dumortier, 10 Romain Ntamack, 9 Antoine Dupont (capt), 8 Gregory Alldritt, 7 Charles Ollivon, 6 Francois Cros, 5 Romain Taofifenua, 4 Thibaud Flament, 3 Uini Atonio, 2 Julien Marchand, 1 Cyril Baille.
Replacements: Peato Mauvaka, Reda Wardi, Sipili Falatea, Bastien Chalureau, Sekou Macalou, Maxime Lucu, Yoram Moefana, Melvyn Jaminet.