Defending Eastbourne men's champion and top seed Taylor Fritz was knocked out of the competition on Wednesday by fellow Californian Mackenzie McDonald.
McDonald recovered from a break down in each set to win 7-6 (7/3), 7-6 (10/8) against the world number nine.
"It's a big win for me. Taylor's a close friend and it's always tough playing your friends. It was a battle out there," McDonald said.
?? Upset alert ??@mackiemacster takes out the #1 seed, Taylor Fritz, 7-6 7-6 to advance in Eastbourne! ??@the_LTA | #RothesayInternational pic.twitter.com/TD1RWg8lHO
— ATP Tour (@atptour) June 28, 2023
The American will face Swede Mikael Ymer in the quarterfinals after he defeated home favourite Liam Broady 6-2, 6-4.
Eighth seed Miomir Kecmanovic struggled past Aleksandar Vukic for a 7-6 (8/6), 6-4 win and will face Frenchman Gregoire Barrere after he upset fifth seed Nicolas Jarry in three sets.