World No 1 and defending champion Daniil Medvedev eased into US Open third round with a 6-2, 7-5, 6-3 win over Arthur Rinderknech of France.
Medvedev goes on to face Wu Yibing who created a piece of tennis history earlier Wednesday after becoming the first man from China to reach the third round in New York.
"He seems to play great. I am expecting a tough match," said Medvedev of Wu who is ranked 174 in the world and came through qualifying.
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KYRGIOS ADVANCES AFTER F-BOMBS, MARIJUANA RANT
Nick Kyrgios claimed fans were smoking marijuana and unleashed a volley of expletives at members of his entourage before advancing to the US Open third round in typically tempestuous fashion on Wednesday.
The volatile Australian was given a code violation during an ugly flashpoint in the third set of his victory over France's Benjamin Bonzi on Louis Armstrong court.
Kyrgios appeared to aim a mouthful of spit in the general direction of his box and then dropped several F-bombs at his team after suffering a break of serve.
Kyrgios went on to drop the set but subsequently recovered his composure to secure a 7-6 (7/3), 6-4, 4-6, 6-4 victory.
MURRAY REACHES US OPEN LAST 32 FOR FIRST TIME IN SIX YEARS
Former champion Andy Murray reached the US Open third round for the first time in six years on Wednesday with a four-set win over American wildcard Emilio Nava.
Murray, who famously ended Britain's 76-year wait for a men's Grand Slam title when he won the US Open in 2012, came out on top 5-7, 6-3, 6-1, 6-0.