Bayer Leverkusen and Villarreal will meet for a fifth time in Europe, with the Spanish side winning three of the last four and going unbeaten overall (W3 D1). All four meetings came in the UEFA Europa League between 2011 and 2016.

Villarreal’s four games against Bayer Leverkusen (W3 D1) is their joint-most without defeat against an opponent in major European competition, also winning three and drawing one of four games against Dynamo Kyiv.